Some cats have a real problem with separation anxiety. If your cat seems anxious at the sight of your suitcase, try leaving your suitcase out for several days before departing. It’s better to have him think that a suitcase in the hallway doesn’t always mean that you are leaving right away. Let him get used to the presence of a suitcase and it will ease the transition between your home and travel days. You can take your time packing and unpacking it over a few days.
You can reduce your cat’s separation anxiety by practicing coming and going so he knows you will always return. If you are just starting out with a kitten or a new cat, you can practice doing this. Start out with a short outing and gradually increasing the length of your separation.
Toys that hide food that can be programmed for timed release are always helpful for cats with separation anxiety.